Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent.[1][2][3] This process is known as “replicative senescence”, or the Hayflick limit. Hayflick’s discovery of mortal cells paved the path for the discovery and understanding of cellular aging molecular pathways.[4] Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things.[5]
The physiological importance for cell senescence has been attributed to prevention of carcinogenesis, and more recently, aging, development, and tissue repair.[6] Senescent cells contribute to the aging phenotype, including frailty syndrome, sarcopenia, and aging-associated diseases.[7] Senescent astrocytes and microglia contribute to neurodegeneration.[8]
Japan is investing a lot into Longevity Research in hopes of keeping us young forever. And recently, they managed to bring about a new kind of vaccine which manages to stop the aging process very reliably through gene editing and biotechnology. This research team intends to move to human trials very soon. The discovery could lead to a similar “fountain of youth” for humans. By modifying just one gene, an international team of researchers was able to extend the life expectancy of mice by 23% — and they think their results may translate to humans. —– Every day is a day closer to the Technological Singularity. Experience Robots learning to walk & think, humans flying to Mars and us finally merging with technology itself. And as all of that happens, we at AI News cover the absolute cutting edge best technology inventions of Humanity.
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TIMESTAMPS:
00:00 Japan’s Plan to cure Aging
02:12 The latest developments in Longevity Research
03:23 What is Cellular Senescence?
05:45 How to become 100 years old
09:15 Last Words
